Piroxicam — a practical guide for pain and arthritis

One tablet can last all day — that’s why piroxicam is still used for long-term pain like arthritis. It’s an NSAID (nonsteroidal anti-inflammatory drug) with a long half-life, so many people take it once a day. This page tells you what it treats, the usual dose, common side effects, and simple safety tips you can use right away.

How piroxicam works and common uses

Piroxicam blocks inflammation chemicals (prostaglandins) that cause pain and swelling. Doctors most often prescribe it for osteoarthritis, rheumatoid arthritis, and other chronic joint problems. Because it lasts a long time, it’s handy for steady, ongoing pain rather than quick short-term relief.

Typical adult dose is 20 mg once daily. Some patients start on lower doses if they’re sensitive, but 20 mg/day is the usual maximum recommended. It’s usually not for children and is often prescription-only where you live.

Safety tips, side effects, and interactions

Common side effects are stomach pain, indigestion, and nausea. The bigger risks are stomach ulcers and bleeding, and higher risk of heart or kidney issues if used long term. People over 65, those with a history of ulcers, or anyone with heart or kidney disease need extra caution.

Serious but less common problems include liver enzyme changes, severe allergic reactions, and photosensitivity (sun-triggered rash). If you notice black stools, severe stomach pain, shortness of breath, yellowing skin, or a new rash, stop the drug and see a doctor.

Piroxicam mixes poorly with some medicines. Watch for interactions with blood thinners (warfarin), SSRIs (bleeding risk), ACE inhibitors or ARBs and diuretics (kidney effects), lithium and methotrexate (levels can rise). Drinking alcohol with NSAIDs increases stomach bleeding risk.

Practical tips: take piroxicam with food to reduce stomach upset. Use the lowest dose that controls symptoms and try to avoid long-term use unless your doctor recommends it. If you’re starting therapy, your doctor may check kidney and liver tests, blood pressure, and ask about stomach bleeding history.

Alternatives include naproxen or ibuprofen for shorter relief, celecoxib for lower GI risk in some patients, and meloxicam which is another long-acting option. Don’t switch or stop medicines without talking to your doctor.

Buying and storage: in many countries piroxicam needs a prescription. If you order online, use a licensed pharmacy that asks for a prescription and shows clear contact details. Store tablets in a cool, dry place away from kids.

If your pain is new, getting worse, or you have other health problems, talk to a healthcare professional. Piroxicam works well for some people, but used the wrong way it can cause real harm — so use it smart and keep an eye on side effects.